The origins of the evolutionary signal used to predict protein-protein interactions.

ABSTRACT:

Background

The correlation of genetic distances between pairs of protein sequence alignments has been used to infer protein-protein interactions. It has been suggested that these correlations are based on the signal of co-evolution between interacting proteins. However, although mutations in different proteins associated with maintaining an interaction clearly occur (particularly in binding interfaces and neighbourhoods), many other factors contribute to correlated rates of sequence evolution. Proteins in the same genome are usually linked by shared evolutionary history and so it would be expected that there would be topological similarities in their phylogenetic trees, whether they are interacting or not. For this reason the underlying species tree is often corrected for. Moreover

SUBMITTER: Swapna LS 

PROVIDER: S-EPMC3537733 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature