MLEP: an R package for exploring the maximum likelihood estimates of penetrance parameters.

ABSTRACT:

Background

Linkage analysis is a useful tool for detecting genetic variants that regulate a trait of interest, especially genes associated with a given disease. Although penetrance parameters play an important role in determining gene location, they are assigned arbitrary values according to the researcher's intuition or as estimated by the maximum likelihood principle. Several methods exist by which to evaluate the maximum likelihood estimates of penetrance, although not all of these are supported by software packages and some are biased by marker genotype information, even when disease development is due solely to the genotype of a single allele.

Findings

Programs for exploring the maximum likelihood estimates of penetrance parameters were developed using the R statistical

SUBMITTER: Sugaya Y 

PROVIDER: S-EPMC3537736 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature