Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load.

ABSTRACT: Mutations are the ultimate source of heritable variation for evolution. Understanding how mutation rates themselves evolve is thus essential for quantitatively understanding many evolutionary processes. According to theory, mutation rates should be minimized for well-adapted populations living in stable environments, whereas hypermutators may evolve if conditions change. However, the long-term fate of hypermutators is unknown. Using a phylogenomic approach, we found that an adapting Escherichia coli population that first evolved a mutT hypermutator phenotype was later invaded by two independent lineages with mutY mutations that reduced genome-wide mutation rates. Applying neutral theory to synonymous substitutions, we dated the emergence of these mutations and inferred that the mutT mutati

SUBMITTER: Wielgoss S 

PROVIDER: S-EPMC3538217 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature