One thousand patients with primary myelofibrosis: the mayo clinic experience.

ABSTRACT:

Objective

To share our decades of experience with primary myelofibrosis and underscore the importance of outcomes research studies in designing clinical trials and interpreting their results.

Patients and methods

One thousand consecutive patients with primary myelofibrosis seen at Mayo Clinic between November 4, 1977, and September 1, 2011, were considered. The International Prognostic Scoring System (IPSS), dynamic IPSS (DIPSS), and DIPSS-plus were applied for risk stratification. Separate analyses were included for patients seen at time of referral (N=1000), at initial diagnosis (N=340), and within or after 1 year of diagnosis (N=660).

Results

To date, 592 deaths and 68 leukemic transformations have been documented. Parameters at initial diagnosis vs time of referra

SUBMITTER: Tefferi A 

PROVIDER: S-EPMC3538387 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature