Germline predictors of androgen deprivation therapy response in advanced prostate cancer.

ABSTRACT:

Objective

To evaluate whether germline variations in genes involved in sex steroid biosynthesis and metabolic pathways predict time to treatment failure for patients with advanced prostate cancer undergoing androgen deprivation therapy (ADT), because there are few known clinical predictors of response.

Patients and methods

In a cohort of 304 patients with advanced prostate cancer undergoing ADT, we genotyped 746 single-nucleotide polymorphisms (SNPs) from 72 genes from germline DNA (680 tagSNPs from 58 genes and 66 candidate SNPs from 20 genes [6 genes common in both]). Association with the primary end point of time to ADT failure was assessed using proportional hazards regression models at the gene level (for genes with tagging SNPs) and at the SNP level. False discovery ra

SUBMITTER: Kohli M 

PROVIDER: S-EPMC3538410 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature