Gastric acid suppression and outcomes in Clostridium difficile infection: a population-based study.

ABSTRACT:

Objective

To evaluate the association of gastric acid suppression medications, including proton pump inhibitors and histamine type 2 blockers, with outcomes in patients with Clostridium difficile infection (CDI) in a population-based cohort.

Patients and methods

To understand the association between acid suppression and outcomes in patients with CDI, we conducted a population-based study in Olmsted County, Minnesota, from January 1, 1991, through December 31, 2005. We compared demographic data and outcomes, including severe, severe-complicated, and recurrent CDI and treatment failure, in a cohort of patients with CDI who were treated with acid suppression medications with these outcomes in a cohort with CDI that was not exposed to acid-suppressing agents.

Results

Of 3

SUBMITTER: Khanna S 

PROVIDER: S-EPMC3538480 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature