Extent of linkage disequilibrium in the domestic cat, Felis silvestris catus, and its breeds.

ABSTRACT: Domestic cats have a unique breeding history and can be used as models for human hereditary and infectious diseases. In the current era of genome-wide association studies, insights regarding linkage disequilibrium (LD) are essential for efficient association studies. The objective of this study is to investigate the extent of LD in the domestic cat, Felis silvestris catus, particularly within its breeds. A custom illumina GoldenGate Assay consisting of 1536 single nucleotide polymorphisms (SNPs) equally divided over ten 1 Mb chromosomal regions was developed, and genotyped across 18 globally recognized cat breeds and two distinct random bred populations. The pair-wise LD descriptive measure (r(2)) was calculated between the SNPs in each region and within each population independently. LD d

SUBMITTER: Alhaddad H 

PROVIDER: S-EPMC3538540 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature