Comparisons of the iron deficient metabolic response in rats fed either an AIN-76 or AIN-93 based diet.

ABSTRACT:

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Background

Previous studies examining the metabolic consequences of dietary iron deficiency have reported elevated serum glucose concentrations in iron-deficient animals. Importantly, the majority of these findings were observed using an earlier version of a laboratory animal diet (AIN-76A) in which the primary carbohydrate source was sucrose - a disaccharide known to negatively impact both glucose and lipid homeostasis. The AIN-76A diet formula was improved in 1993 (AIN-93) to optimize animal nutrition with a major change being the substitution of cornstarch for sucrose. Therefore, we sought to examine the effects of iron deficiency on steady-state glucose homeostasis and the hepatic expression of glucose- and lipid-related genes in rats fed an iron-deficient di

SUBMITTER: Davis MR 

PROVIDER: S-EPMC3538620 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature