Molecular characterization of the feline T-cell receptor γ alternate reading frame protein (TARP) ortholog.

ABSTRACT: T-cell receptor γ alternate reading frame protein (TARP) is expressed by human prostate epithelial, prostate cancer, and mammary cancer cells, but is not found in normal mammary tissue. To date, this protein has only been described in humans. Additionally, no animal model has been established to investigate the potential merits of TARP as tumor marker or a target for adoptive tumor immunotherapy. In this study conducted to characterize feline T-cell receptor γ sequences, constructs very similar to human TARP transcripts were obtained by RACE from the spleen and prostate gland of cats. Transcription of TARP in normal, hyperplastic, and neoplastic feline mammary tissues was evaluated by conventional RT-PCR. In felines similarly to the situation reported in humans, a C-region encoding two ope

SUBMITTER: Weiss AT 

PROVIDER: S-EPMC3539119 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature