Central hemodynamics in prehypertension: effect of the β-adrenergic antagonist nebivolol.

ABSTRACT: The aim of the current study was to characterize the effects of the novel β-adrenergic antagonist nebivolol on central aortic blood pressures, arterial properties, and nitroxidergic activity in individuals with prehypertension. Prehypertension is emerging as a major risk factor for several adverse cardiovascular consequences. Increased pulse wave velocity, aortic augmentation index, and aortic blood pressures have been linked with augmented risk of cardiovascular disease and mortality. While the effects of antihypertensive drugs on these parameters in hypertensive patients have been studied, there are limited data so far in prehypertension. Fifty individuals with prehypertension were randomized to either nebivolol (5 mg per day) or placebo in a double-blind clinical trial. Patients underwe

SUBMITTER: Davis JT 

PROVIDER: S-EPMC3539183 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature