Enantioselective synthesis of the C1-C11 fragment of tedanolide C.

ABSTRACT: A convergent synthesis of the protected C(1)-C(11) fragment 6 of the targeted enantiomer of tedanolide C is described. The key step of the synthesis is the Felkin-Ahn addition of vinyl iodide 7 to aldehyde 8 that proceeds in 80% yield with 4:1 diastereoselectivity.

SUBMITTER: Geist JG 

PROVIDER: S-EPMC3539184 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature