Association between single-nucleotide polymorphisms of BRAF and papillary thyroid carcinoma in a Chinese population.

ABSTRACT:

Background

Papillary thyroid cancer (PTC) is a common malignancy that frequently harbors a high prevalence of somatic mutations in the oncogenic BRAF gene. As a novel prognostic molecular marker, this gene has drawn much attention in recent years for its potential utility in the risk prognosis and management of PTC. However, the contribution of the germline variants in this gene to PTC remains unclear. The study herein was aimed to investigate the potential association between the inherited BRAF variants and PTC based on a case-control study.

Methods

We selected four single-nucleotide polymorphisms (SNPs) and took a systematic step to interrogate whether these SNPs of BRAF are associated with PTC risk by genotyping these SNPs from 368 patients with PTC and 564 healthy contro

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC3539251 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature