Molecular targeted therapies in advanced gastric cancer: does tumor histology matter?

ABSTRACT: It is increasingly recognized that gastric cancer is a heterogeneous disease which may be divided into subgroups based on histological, anatomical, epidemiological and molecular classifications. Distinct molecular drivers and tumor biology, and thus different treatment targets and predictive biomarkers, may be implicated in each subtype. However, there is little evidence in the literature regarding the correlation among these different classifications, and particularly the molecular aberrations present in each subtype. In this review, we approach advanced gastric cancer (AGC) by presenting aberrant molecular pathways and their potential therapeutic targets in gastric cancer according to histological and anatomical classification, dividing gastric cancer into proximal nondiffuse, distal non

SUBMITTER: Wong H 

PROVIDER: S-EPMC3539290 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature