Non-metastatic unresected paediatric non-rhabdomyosarcoma soft tissue sarcomas: results of a pooled analysis from United States and European groups.

ABSTRACT:

Background

Non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) with initially unresected tumours represent a particular subset of patients with a poor outcome. Various international research groups pooled their data in a joint study in order to investigate prognostic variables and treatment modalities.

Methods

The study population consisted of 304 patients <21 years old treated between 1980 and 2005 using a multimodality therapeutic strategy.

Results

Synovial sarcoma and malignant peripheral nerve sheath tumour (MPNST) were the most frequent histotypes. Most patients received initial chemotherapy: major responses were recorded in 41% and minor in 16% of cases. Overall survival (OS) was 60.0% and 51.5% at 5 and 10 years, respectively, and it was significantly associated

SUBMITTER: Ferrari A 

PROVIDER: S-EPMC3539303 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature