Cause, timing, and location of death in the Single Ventricle Reconstruction trial.

ABSTRACT:

Objectives

The Single Ventricle Reconstruction trial randomized 555 subjects with a single right ventricle undergoing the Norwood procedure at 15 North American centers to receive either a modified Blalock-Taussig shunt or right ventricle-to-pulmonary artery shunt. Results demonstrated a rate of death or cardiac transplantation by 12 months postrandomization of 36% for the modified Blalock-Taussig shunt and 26% for the right ventricle-to-pulmonary artery shunt, consistent with other publications. Despite this high mortality rate, little is known about the circumstances surrounding these deaths.

Methods

There were 164 deaths within 12 months postrandomization. A committee adjudicated all deaths for cause and recorded the timing, location, and other factors for each event.

SUBMITTER: Ohye RG 

PROVIDER: S-EPMC3539407 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature