Molecular epidemical characteristics of Lamivudine resistance mutations of HBV in southern China.

ABSTRACT:

Background

Lamivudine (LMV), as the preferred oral drug for use in treatment of HBV, always results in development of resistance mutations after long-term treatment. In this study we investigated chronic hepatitis B (CHB) patients in southern China to determine whether different HBV genotypes affect the incidence of LMV resistance mutations.

Material/methods

The study recruited 185 CHB patients living in southern China. Enzyme-linked immunosorbent assay was used to test for HBV serological markers, and HBV DNA was quantified by real-time PCR. Sequencing was performed to detect HBV genotypes and mutations.

Results

There were 49.19% (91/185) CHB patients with HBV resistant to LMV. Only 2 genotypes were found: B and C; 62.16% (115/185) of patients were infected with geno

SUBMITTER: Li SY 

PROVIDER: S-EPMC3539467 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature