Lack of association between the c.544G>A polymorphism of the heme oxygenase-2 gene and age-related macular degeneration.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is a primary cause of blindness among the elderly in developed countries. The nature of AMD is complex and includes both environmental and hereditary factors. Oxidative stress is thought to be essential in AMD pathogenesis. Iron is suggested to be implicated in the pathogenesis of AMD through the catalysis of the production of reactive oxygen species, which can damage the retina. Heme oxygenase-2 is capable of degradation of heme producing free iron ions, thus, diversity in heme oxygenase-2 gene may contribute to AMD. In the present work we analyzed the association between the c.544G>A polymorphism of the heme oxygenase-2 gene (HMOX2) (rs1051308) and AMD.

Material/methods

This study enrolled 276 AMD patients and 105 sex- and

SUBMITTER: Wysokinski D 

PROVIDER: S-EPMC3539623 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature