Associations of obesity genes with obesity-related outcomes in multiethnic children.

ABSTRACT:

Background and aims

Genome-wide association studies (GWAS) have identified several loci that are associated with body mass index (BMI = kg/m(2)). However, little is known regarding whether the genetic basis of BMI differs among children of diverse racial/ethnic backgrounds, how the cumulative effect of these genes influences weight, or the contribution of these variants to body composition. This study examined the association between 17 GWAS-identified loci located in 16 genes and body-composition phenotypes in a multiethnic pediatric sample and evaluated the association of a composite genetic risk score with these phenotypes.

Methods

Anthropometric measures of BMI, waist circumference and waist-to-hip ratio were obtained in a sample of 298 children. Lean and fat mass were o

SUBMITTER: Klimentidis YC 

PROVIDER: S-EPMC3541020 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature