The plant short-chain dehydrogenase (SDR) superfamily: genome-wide inventory and diversification patterns.

ABSTRACT:

Background

Short-chain dehydrogenases/reductases (SDRs) form one of the largest and oldest NAD(P)(H) dependent oxidoreductase families. Despite a conserved 'Rossmann-fold' structure, members of the SDR superfamily exhibit low sequence similarities, which constituted a bottleneck in terms of identification. Recent classification methods, relying on hidden-Markov models (HMMs), improved identification and enabled the construction of a nomenclature. However, functional annotations of plant SDRs remain scarce.

Results

Wide-scale analyses were performed on ten plant genomes. The combination of hidden Markov model (HMM) based analyses and similarity searches led to the construction of an exhaustive inventory of plant SDR. With 68 to 315 members found in each analysed genome, the i

SUBMITTER: Moummou H 

PROVIDER: S-EPMC3541173 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature