Genomic signatures characterize leukocyte infiltration in myositis muscles.

ABSTRACT:

Background

Leukocyte infiltration plays an important role in the pathogenesis and progression of myositis, and is highly associated with disease severity. Currently, there is a lack of: efficacious therapies for myositis; understanding of the molecular features important for disease pathogenesis; and potential molecular biomarkers for characterizing inflammatory myopathies to aid in clinical development.

Methods

In this study, we developed a simple model and predicted that 1) leukocyte-specific transcripts (including both protein-coding transcripts and microRNAs) should be coherently overexpressed in myositis muscle and 2) the level of over-expression of these transcripts should be correlated with leukocyte infiltration. We applied this model to assess immune cell infiltrati

SUBMITTER: Zhu W 

PROVIDER: S-EPMC3541209 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature