Comparative regional pupillography as a noninvasive biosensor screening method for diabetic retinopathy.

ABSTRACT:

Purpose

We describe infrared regional pupillometry as an objective comparative assessment of midperipheral to central retinal sensitivity and to correlate with midperipheral retinal ischemia in diabetic subjects.

Methods

We tested 12 normal and 17 diabetic subjects using bilateral infrared pupillometry. The diabetic cohort included seven subjects without, five with mild, three with moderate, and two with severe non-proliferative diabetic retinopathy (NPDR). Central and annular stimuli of varying intensity were presented to one eye, and pupillary amplitude and constriction velocity were measured from both eyes. Light stimulus of increasing intensity was presented as 20 consecutive trials (stimulus duration of 300 ms with 3000 ms intervals). The ratio of central to peripheral

SUBMITTER: Ortube MC 

PROVIDER: S-EPMC3541948 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature