New approaches for unravelling reassortment pathways.

ABSTRACT:

Background

Every year the human population encounters epidemic outbreaks of influenza, and history reveals recurring pandemics that have had devastating consequences. The current work focuses on the development of a robust algorithm for detecting influenza strains that have a composite genomic architecture. These influenza subtypes can be generated through a reassortment process, whereby a virus can inherit gene segments from two different types of influenza particles during replication. Reassortant strains are often not immediately recognised by the adaptive immune system of the hosts and hence may be the source of pandemic outbreaks. Owing to their importance in public health and their infectious ability, it is essential to identify reassortant influenza strains in order to under

SUBMITTER: Svinti V 

PROVIDER: S-EPMC3541980 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature