Extinction learning deficit in a rodent model of attention-deficit hyperactivity disorder.

ABSTRACT:

Background

Deficient operant extinction has been hypothesized to be constitutive of ADHD dysfunction. In order to elucidate the behavioral mechanisms underlying this deficit, the performance of an animal model of ADHD, the spontaneously hypertensive rat (SHR), was compared against the performance of a control strain, the Wistar-Kyoto rat (WKY) during extinction.

Method

Following extensive training of lever pressing under variable interval schedules of food reinforcement (reported previously), SHR and WKY rats were exposed to two sessions of extinction training. Extinction data was analyzed using the Dynamic Bi-Exponential Refractory Model (DBERM) of operant performance. DBERM assumes that operant responses are organized in bouts separated by pauses; during extinction, bouts

SUBMITTER: Brackney RJ 

PROVIDER: S-EPMC3542014 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature