Structural attributes for the recognition of weak and anomalous regions in coiled-coils of myosins and other motor proteins.

ABSTRACT:

Background

Coiled-coils are found in different proteins like transcription factors, myosin tail domain, tropomyosin, leucine zippers and kinesins. Analysis of various structures containing coiled-coils has revealed the importance of electrostatic and hydrophobic interactions. In such domains, regions of different strength of interactions need to be identified since they could be biologically relevant.

Findings

We have updated our coiled-coil validation webserver, now called COILCHECK+, where new features were added to efficiently identify the strength of interaction at the interface region and measure the density of charged residues and hydrophobic residues. We have examined charged residues and hydrophobic ladders, using a new algorithm called CHAHO, which is incorporated w

SUBMITTER: Sunitha MS 

PROVIDER: S-EPMC3542152 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature