Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population.

ABSTRACT:

Introduction

Cigarette smoke and alcohol can generate reactive oxygen species, which may induce DNA double-strand breaks (DSBs), the most serious DNA lesion. In humans, DSBs are repaired mainly by non-homologous end joining and homologous recombination repair (HRR). Several polymorphisms in the DNA repair gene have been extensively studied in the association with various human cancers. In the present work we investigated the association between polymorphisms of two HRR genes, XRCC2 and RAD51, and tobacco- and alcohol-related larynx cancer in a Polish population.

Material and methods

Two polymorphisms of the XRCC2 gene, -41657C > T (rs718282) and 31479G > A (rs3218536), as well as one polymorphism of the RAD51 gene, -135G > C (rs1801320), were investigated by PCR-RFLP in 253

SUBMITTER: Romanowicz-Makowska H 

PROVIDER: S-EPMC3542498 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature