Interleukin-17A and interleukin-23 in morphea.

ABSTRACT:

Introduction

Morphea is a disease included in the group of scleroderma type autoimmune diseases. Interleukin (IL)-17A may play a role at every stage of its pathogenesis. The study aimed at evaluation of IL-17A and IL-23 (as the main cytokine which is supposed to stimulate and maintain synthesis of IL-17) in pathogenesis of morphea.

Material and methods

The studies were performed on 41 blood samples from patients with morphea. Skin was sampled from 29 patients. The evaluation included: (1) expression of IL-17A and IL-23 genes in peripheral blood mononuclear cells (PBMC) using real-time polymerase chain reaction (PCR), (2) plasma concentrations of IL-17A and IL-23 using ELISA, (3) expression of IL-17A and IL-23 genes in skin using real-time PCR.

Results

The results of g

SUBMITTER: Danczak-Pazdrowska A 

PROVIDER: S-EPMC3542501 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature