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Genomic analysis of two novel human enterovirus C genotypes found in respiratory samples from Peru.

ABSTRACT: We report the discovery of two enteroviruses detected in nasopharyngeal samples obtained from subjects with respiratory disease in Peru. Phylogenetic analysis indicated that both viruses belong to a clade within the species Human enterovirus C, which includes the recently characterized human enteroviruses 109 and 104. Members of this clade have undergone significant genomic rearrangement, as indicated by deletions in the hypervariable region of the 5' UTR and the VP1 protein, as well as recombination within the non-structural genes. Our findings and review of published sequences suggests that several novel human enterovirus C serotypes are currently circulating worldwide.

SUBMITTER: Tokarz R

PROVIDER: S-EPMC3542718 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Genomic analysis of two novel human enterovirus C genotypes found in respiratory samples from Peru.

Tokarz Rafal R Hirschberg David L DL Sameroff Stephen S Haq Saddef S Luna Giannina G Bennett Andrew J AJ Silva Maria M Leguia Mariana M Kasper Matthew M Bausch Daniel G DG Lipkin W Ian WI

The Journal of general virology 20121003 Pt 1

We report the discovery of two enteroviruses detected in nasopharyngeal samples obtained from subjects with respiratory disease in Peru. Phylogenetic analysis indicated that both viruses belong to a clade within the species Human enterovirus C, which includes the recently characterized human enteroviruses 109 and 104. Members of this clade have undergone significant genomic rearrangement, as indicated by deletions in the hypervariable region of the 5' UTR and the VP1 protein, as well as recombin ...[more]

PMID: 23034595

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