Accumulation of nucleotide substitutions occurring during experimental transmission of foot-and-mouth disease virus.

ABSTRACT: Analysis of full-genome sequences was previously used to trace the origin and transmission pathways of foot-and-mouth disease virus (FMDV) outbreaks in the UK in 2001 and 2007. Interpretation of these data was sometimes at variance with conventional epidemiological tracing, and was also used to predict the presence of undisclosed infected premises that were later discovered during serological surveillance. Here we report the genome changes associated with sequential passage of a highly BHK-21-cell-adapted (heparan sulphate-binding) strain of FMDV arising from two independent transmission chains in cattle. In vivo virus replication rapidly selected for a wild-type variant with an amino acid substitution at VP3(56). Full-genome sequence analysis clearly demonstrated sequence divergence durin

SUBMITTER: Juleff N 

PROVIDER: S-EPMC3542721 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature