Association between GABA(A) receptor subunit gene cluster and zolpidem-induced complex sleep behaviors in Han Chinese.

ABSTRACT:

Study objectives

To investigate and elucidate the role of GABA(A) receptor subunits, specifically the 2 genetic markers at the GABA(A) α1 and GABA(A) α6 receptors, in zolpidem-induced complex sleep behaviors (CSBs).

Design

Genetic association study.

Setting

Kaohsiung Medical University-affiliated hospitals, Kaohsiung, Taiwan.

Patients

30 zolpidem-induced CSB subjects and 37 controls.

Interventions

N/A.

Measurements and results

The χ(2) test demonstrated an association between the A15G variant at the GABA(A) α1 receptor subunit gene and zolpidem-induced CSBs (P = 0.007). The adjusted odds ratio of the GABA(A) α1 receptor subunit genotype for the risk of zolpidem-induced CSBs was approximately 10 (OR = 9.99, 95% CI = 1.82, 74.87; P = 0.013).

Conc

SUBMITTER: Tsai JH 

PROVIDER: S-EPMC3543054 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature