Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes.

ABSTRACT:

Background

High serum triglyceride (TG) levels is an established risk factor for coronary heart disease (CHD). Fat is stored in the form of TGs in human adipose tissue. We hypothesized that gene co-expression networks in human adipose tissue may be correlated with serum TG levels and help reveal novel genes involved in TG regulation.

Methods

Gene co-expression networks were constructed from two Finnish and one Mexican study sample using the blockwiseModules R function in Weighted Gene Co-expression Network Analysis (WGCNA). Overlap between TG-associated networks from each of the three study samples were calculated using a Fisher's Exact test. Gene ontology was used to determine known pathways enriched in each TG-associated network.

Results

We measured gene expression

SUBMITTER: Haas BE 

PROVIDER: S-EPMC3543280 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature