Pandemic influenza A virus codon usage revisited: biases, adaptation and implications for vaccine strain development.

ABSTRACT:

Background

Influenza A virus (IAV) is a member of the family Orthomyxoviridae and contains eight segments of a single-stranded RNA genome with negative polarity. The first influenza pandemic of this century was declared in April of 2009, with the emergence of a novel H1N1 IAV strain (H1N1pdm) in Mexico and USA. Understanding the extent and causes of biases in codon usage is essential to the understanding of viral evolution. A comprehensive study to investigate the effect of selection pressure imposed by the human host on the codon usage of an emerging, pandemic IAV strain and the trends in viral codon usage involved over the pandemic time period is much needed.

Results

We performed a comprehensive codon usage analysis of 310 IAV strains from the pandemic of 2009. Highly bias

SUBMITTER: Goni N 

PROVIDER: S-EPMC3543350 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature