Buprenorphine/Naloxone and methadone effects on laboratory indices of liver health: a randomized trial.

ABSTRACT:

Background

Buprenorphine/naloxone (BUP) and methadone (MET) are efficacious treatments for opioid dependence, although concerns about a link between BUP and drug-induced hepatitis have been raised. This study compares the effects of BUP and MET on liver health in opioid-dependent participants.

Methods

This was a randomized controlled trial of 1269 opioid-dependent participants seeking treatment at 8 federally licensed opioid treatment programs and followed for up to 32 weeks between May 2006 and August 2010; 731 participants met "evaluable" criteria defined as completing 24 weeks of medication and providing at least 4 blood samples for transaminase testing. Participants were randomly assigned to receive BUP or MET for 24 weeks. Shift table analysis determined how many evalua

SUBMITTER: Saxon AJ 

PROVIDER: S-EPMC3543467 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature