Identity-by-descent-based heritability analysis in the Northern Finland Birth Cohort.

ABSTRACT: For most complex traits, only a small proportion of heritability is explained by statistically significant associations from genome-wide association studies (GWAS). In order to determine how much heritability can potentially be explained through larger GWAS, several different approaches for estimating total narrow-sense heritability from GWAS data have recently been proposed. These methods include variance components with relatedness estimates from allele-sharing, variance components with relatedness estimates from identity-by-descent (IBD) segments, and regression of phenotypic correlation on relatedness estimates from IBD segments. These methods have not previously been compared on real or simulated data. We analyze the narrow-sense heritability of nine metabolic traits in the Northern F

SUBMITTER: Browning SR 

PROVIDER: S-EPMC3543768 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature