Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma.

ABSTRACT: Platelet-derived growth factor receptor alpha-positive oligodendrocyte progenitor cells (OPC) located within the mature central nervous system may remain quiescent, proliferate, or differentiate into oligodendrocytes. Human glioblastoma multiforme tumors often contain rapidly proliferating oligodendrocyte lineage transcription factor 2 (Olig2)-positive cells that resemble OPCs. In this study, we sought to identify candidate pathways that promote OPC differentiation or quiescence rather than proliferation. Gene expression profiling conducted in both normal murine OPCs and highly proliferative Olig2-positive glioma cells identified all the transcripts associated with the highly proliferative state of these cells and showed that among the various cell types found within the brain, Olig2-posit

SUBMITTER: Dougherty JD 

PROVIDER: S-EPMC3543775 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature