Association of circulating adiponectin levels with progression of radiographic joint destruction in rheumatoid arthritis.

ABSTRACT:

Background

Adipokines have inflammatory and immunomodulatory properties that may contribute to erosive joint damage. The association of serum adipokine levels with progression of radiographic joint damage in patients with rheumatoid arthritis (RA) was prospectively explored.

Methods

Patients with RA underwent serum adipokine assessment (adiponectin, resistin, leptin) at three timepoints and hand/feet x-rays, scored using the Sharp-van der Heijde Score (SHS), at baseline and the third study visit, separated by an average of 39±4 months. The associations of baseline and average adipokine levels with change in SHS were explored, adjusting for pertinent confounders.

Results

Of the 152 patients studied, 85 (56%) showed an increase in SHS (defined as >0 SHS units). Among th

SUBMITTER: Giles JT 

PROVIDER: S-EPMC3543946 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature