Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis.

ABSTRACT: Caloric restriction (CR) mitigates many detrimental effects of aging and prolongs life span. CR has been suggested to increase mitochondrial biogenesis, thereby attenuating age-related declines in mitochondrial function, a concept that is challenged by recent studies. Here we show that lifelong CR in mice prevents age-related loss of mitochondrial oxidative capacity and efficiency, measured in isolated mitochondria and permeabilized muscle fibers. We find that these beneficial effects of CR occur without increasing mitochondrial abundance. Whole-genome expression profiling and large-scale proteomic surveys revealed expression patterns inconsistent with increased mitochondrial biogenesis, which is further supported by lower mitochondrial protein synthesis with CR. We find that CR decreases

SUBMITTER: Lanza IR 

PROVIDER: S-EPMC3544078 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature