Lipoprotein phospholipase A2 and cerebral microbleeds in the Framingham Heart Study.

ABSTRACT:

Background and purpose

Cerebral microbleeds (CMB) attributable to cerebral amyloid angiopathy generally occur in lobar regions, whereas those attributable to hypertensive vasculopathy are deep. Inflammation may be an underlying mechanism for CMB, with varying associations according to CMB location. Lipoprotein phospholipase-A2 (Lp-PLA2) is a circulating enzyme marker of vascular inflammation associated with risk of ischemic stroke and dementia. We hypothesized that higher Lp-PLA2 levels would be related to higher prevalence of CMB, with possible regional specificity.

Methods

Framingham Offspring participants aged 65 years or older with available Lp-PLA2 measures and brain magnetic resonance imaging were included. Logistic regression models were used to relate Lp-PLA2 activit

SUBMITTER: Romero JR 

PROVIDER: S-EPMC3544291 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature