Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization.

ABSTRACT: Substantial evidence supports the concept that cancers are organized in a cellular hierarchy with cancer stem cells (CSC) at the apex. To date, the primary evidence for CSCs derives from transplantation assays, which have known limitations. In particular, they are unable to report on the fate of cells within the original human tumor. Because of the difficulty in measuring tumor characteristics in patients, cellular organization and other aspects of cancer dynamics have not been quantified directly, although they likely play a fundamental role in tumor progression and therapy response. As such, new approaches to study CSCs in patient-derived tumor specimens are needed. In this study, we exploited ultradeep single-molecule genomic data derived from multiple microdissected colorectal cancer g

SUBMITTER: Sottoriva A 

PROVIDER: S-EPMC3544316 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature