Role of vaspin in human eating behaviour.

ABSTRACT:

Objective

The adipokine vaspin (visceral adipose tissue derived serine protease inhibitor, serpinA12) follows a meal-related diurnal variation in humans and intracerebroventricular vaspin administration leads to acutely reduced food intake in db/db mice. We therefore hypothesized that vaspin may play a role in human eating behaviour.

Materials and methods

We measured serum vaspin concentrations in 548 subjects from a self-contained population of Sorbs (Germany) who underwent detailed metabolic testing including eating behaviour assessments using the three-factor eating questionnaire. In addition, genetic variation within vaspin was assessed by genotyping 28 single nucleotide polymorphisms (SNPs) in all study subjects.

Results

Serum vaspin concentrations correlated pos

SUBMITTER: Breitfeld J 

PROVIDER: S-EPMC3544656 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature