Association of glutathione S transferases polymorphisms with glaucoma: a meta-analysis.

ABSTRACT:

Background

Glutathione S transferase (GST) polymorphisms have been considered risk factors for the development of glaucoma, including primary open angle glaucoma (POAG) and other types of glaucoma. However, the results remain controversial. In this study, we have conducted a meta-analysis to assess the association between polymorphisms of GSTM1, GSTT1 and GSTP1 and glaucoma risk.

Methods

Published literature from PubMed and other databases were retrieved. All studies evaluating the association between GSTM1, GSTT1 and GSTP1 polymorphisms and glaucoma risk were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model.

Results

Twelve studies on GSTM1 (1109 cases and 844 controls), ten studies on GSTT1 (709 ca

SUBMITTER: Yu Y 

PROVIDER: S-EPMC3544666 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature