Functional relevance for associations between genetic variants and systemic lupus erythematosus.

ABSTRACT: Systemic lupus erythematosus (SLE) is a serious prototype autoimmune disease characterized by chronic inflammation, auto-antibody production and multi-organ damage. Recent association studies have identified a long list of loci that were associated with SLE with relatively high statistical power. However, most of them only established the statistical associations of genetic markers and SLE at the DNA level without supporting evidence of functional relevance. Here, using publically available datasets, we performed integrative analyses (gene relationship across implicated loci analysis, differential gene expression analysis and functional annotation clustering analysis) and combined with expression quantitative trait loci (eQTLs) results to dissect functional mechanisms underlying the associ

SUBMITTER: Deng FY 

PROVIDER: S-EPMC3544818 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature