Polymorphism in the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs.

ABSTRACT:

Background

The ELOVL fatty acid elongase 6 (ELOVL6), the only elongase related to de novo lipogenesis, catalyzes the rate-limiting step in the elongation cycle by controlling the fatty acid balance in mammals. It is located on pig chromosome 8 (SSC8) in a region where a QTL affecting palmitic, and palmitoleic acid composition was previously detected, using an Iberian x Landrace intercross. The main goal of this work was to fine-map the QTL and to evaluate the ELOVL6 gene as a positional candidate gene affecting the percentages of palmitic and palmitoleic fatty acids in pigs.

Methodology and principal findings

The combination of a haplotype-based approach and single-marker analysis allowed us to identify the main, associated interval for the QTL, in which the ELOVL6 gene was

SUBMITTER: Corominas J 

PROVIDER: S-EPMC3544903 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature