Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.

ABSTRACT: Schizophrenia is a psychiatric disorder associated with atypical handedness and language lateralization. However, the molecular mechanisms underlying these functional changes are still poorly understood. Therefore, the present study was aimed at investigating whether variation in schizophrenia-related genes modulates individual lateralization patterns. To this end, we genotyped 16 single nucleotide polymorphisms that have previously been linked to schizophrenia on a meta-analysis level in a sample of 444 genetically unrelated healthy participants and examined the association of these polymorphisms with handedness, footedness and language lateralization. We found a significant association of the cholecystokinin-A receptor (CCKAR) gene variation rs1800857 and language lateralization assessed

SUBMITTER: Ocklenburg S 

PROVIDER: S-EPMC3544920 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature