Ontology highlight
ABSTRACT:
SUBMITTER: Olivier-Van Stichelen S
PROVIDER: S-EPMC3545199 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Olivier-Van Stichelen S S Drougat L L Dehennaut V V El Yazidi-Belkoura I I Guinez C C Mir A-M AM Michalski J-C JC Vercoutter-Edouart A-S AS Lefebvre T T
Oncogenesis 20121210
Nuclear and cytoplasmic O-GlcNAc transferase (OGT) is a unique and universally expressed enzyme catalyzing O-GlcNAcylation of thousands of proteins. Although OGT interferes with many crucial intracellular processes, including cell cycle, only few studies have focused on elucidating the precise role of the glycosyltransferase during cell cycle entry. We first demonstrated that starved MCF7 cells reincubated with serum quickly induced a significant OGT increase concomitantly to activation of PI3K ...[more]