Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3545653 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols.
Li Yuanpei Y Xiao Wenwu W Xiao Kai K Berti Lorenzo L Luo Juntao J Tseng Harry P HP Fung Gabriel G Lam Kit S KS
Angewandte Chemie (International ed. in English) 20120117 12
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Project description:Natural fruits contain a large variety of cis-diols. However, due to the lack of a high-resolution sensor that can simultaneously identify all cis-diols without a need of complex sample pretreatment, direct and rapid analysis of fruits in a hand-held device has never been previously reported. Nanopore, a versatile single molecule sensor, can be specially engineered to perform this task. A hetero-octameric Mycobacterium smegmatis porin A (MspA) nanopore modified with a sole phenylboronic acid (PBA) adapter is prepared. This engineered MspA accurately recognizes 1,2-diphenols, alditols, α-hydroxy acids and saccharides in prune, grape, lemon, different varieties of kiwifruits and commercial juice products. Assisted with a custom machine learning program, an accuracy of 99.3% is reported and the sample pretreatment is significantly simplified. Enantiomers such as DL-malic acids can also be directly identified, enabling sensing of synthetic food additives. Though demonstrated with fruits, these results suggest wide applications of nanopore in food and drug administration uses.
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2024-09-09 | GSE276124 | GEO