RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes.

ABSTRACT:

Objective

Vascular remodeling diseases (VRD) are mainly characterized by inflammation and a vascular smooth muscle cells (VSMCs) proproliferative and anti-apoptotic phenotype. Recently, the activation of the advanced glycation endproducts receptor (RAGE) has been shown to promote VSMC proliferation and resistance to apoptosis in VRD in a signal transducer and activator of transcription (STAT)3-dependant manner. Interestingly, we previously described in both cancer and VRD that the sustainability of this proproliferative and antiapoptotic phenotype requires activation of the transcription factor NFAT (nuclear factor of activated T-cells). In cancer, NFAT activation is dependent of the oncoprotein provirus integration site for Moloney murine leukemia virus (Pim1), which is regulated

SUBMITTER: Meloche J 

PROVIDER: S-EPMC3545710 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature