A genomic scale map of genetic diversity in Trypanosoma cruzi.

ABSTRACT:

Background

Trypanosoma cruzi, the causal agent of Chagas Disease, affects more than 16 million people in Latin America. The clinical outcome of the disease results from a complex interplay between environmental factors and the genetic background of both the human host and the parasite. However, knowledge of the genetic diversity of the parasite, is currently limited to a number of highly studied loci. The availability of a number of genomes from different evolutionary lineages of T. cruzi provides an unprecedented opportunity to look at the genetic diversity of the parasite at a genomic scale.

Results

Using a bioinformatic strategy, we have clustered T. cruzi sequence data available in the public domain and obtained multiple sequence alignments in which one or two alleles fr

SUBMITTER: Ackermann AA 

PROVIDER: S-EPMC3545726 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature