Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation.
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ABSTRACT:
SUBMITTER: Jiang JF
PROVIDER: S-EPMC3545878 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation.
Jiang Jing-Fei JF Wang Yu-Gang YG Hu Jun J Lei Fan F Kheir Michael M MM Wang Xin-Pei XP Chai Yu-Shuang YS Yuan Zhi-Yi ZY Lu Xi X Xing Dong-Ming DM Du Feng F Du Li-Jun LJ
PloS one 20130115 1
The purpose of this study was to assess the effects of berberine (BBR) on thermoregulation in mice exposed to hot (40°C) and cold (4°C) environmental conditions. Four groups of mice were assembled with three different dosages of BBR (0.2, 0.4, and 0.8 mg/kg) and normal saline (control). In room temperature, our largest dosage of BBR (0.8 mg/kg) can reduce rectal temperatures (Tc) of normal mice. In hot conditions, BBR can antagonize the increasing core body temperature and inhibit the expression ...[more]
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