A common variant highly associated with plasma VEGFA levels also contributes to the variation of both LDL-C and HDL-C.

ABSTRACT: Vascular endothelial growth factor A (VEGFA) is among the most-significant stimulators of angiogenesis. Its effect on cardiovascular diseases and on the variation of related risk factors such as lipid parameters is considered important, although as yet unclear. Recently, we identified four common variants (rs6921438, rs4416670, rs6993770, and rs10738760) that explain up to 50% of the heritability of plasma VEGFA levels. In the present study, we aimed at assessing the contribution of these variants to the variation of blood lipid levels (including apoE, triglycerides, total cholesterol, low- and high-density lipoprotein cholesterol levels (LDL-C and HDL-C)] in healthy subjects. The effect of these single-nucleotide polymorphisms (SNPs) on lipid levels was assessed using linear regression in

SUBMITTER: Stathopoulou MG 

PROVIDER: S-EPMC3546029 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature