The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users.

ABSTRACT:

Background

Prior studies have separately examined the effects of dronabinol (oral THC) on cannabis withdrawal, cognitive performance, and the acute effects of smoked cannabis. A single study examining these clinically relevant domains would benefit the continued evaluation of dronabinol as a potential medication for the treatment of cannabis use disorders.

Methods

Thirteen daily cannabis smokers completed a within-subject crossover study and received 0, 30, 60 and 120mg dronabinol per day for 5 consecutive days. Vital signs and subjective ratings of cannabis withdrawal, craving and sleep were obtained daily; outcomes under active dose conditions were compared to those obtained under placebo dosing. On the 5th day of medication maintenance, participants completed a comprehens

SUBMITTER: Vandrey R 

PROVIDER: S-EPMC3546149 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature